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First, that the GSH binding site(s) on the structure of the capsid is completely different than the locations of the BSO resistant mutations

however, it does appear to have the potential to slow down the process by possibly preventing naturally occurring FOXO4-mediated resistance to apoptosis during senescence

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Some patients choose to transition to a lower maintenance dose rather than stopping completely, though this requires discussion with their provider

So far, uterine bleeding has not been a major concern in the official reports